The Impact of Retroactivity on the Input/output Static Characteristics of a Signaling Component
نویسندگان
چکیده
In prior work, we have shown that just as in many engineering systems, impedance-like effects appear at the interconnection of biomolecular systems. These effects are called retroactivity, to extend the notion of impedance to biological systems. Signaling components, such as covalent modification cycles, play a central role in the transmission of signals within a cell and from outside the cell. They are typically found in highly interconnected architectures in which a component has several downstream clients. In this paper, we investigate how retroactivity due to downstream clients affects the input/output steady state characteristics of a covalent modification cycle.
منابع مشابه
THE IMPACT OF RETROACTIVITY ON THE BEHAVIOR OF BIO-MOLECULAR SYSTEMS A Review of Recent Results
Modularity is a powerful property for analyzing the behavior of a system on the basis of the behavior of its components. According to this property, any two components maintain their behavior unchanged upon interconnection. Is modularity a natural property of bio-molecular networks? In this review, we summarize recent theoretical and experimental results that demonstrate that the answer to this...
متن کاملImpact of Retroactivity on Transcriptional Components
• Studies show that interconnection of biological parts are vulnerable to Retroactivity, an effect that arises when an upstream system fails to preserve its input/output behavior upon connection to a downstream system. This effect alters both the dynamic as well as the steady state response of the upstream system. Abstract Impact of Retroactivity on Transcriptional Components Shridhar Jayanthi*...
متن کاملThe Impact of Different Frequency Patterns on the Syntactic Production of a 6-year-old EFL Home Learner: A Case Study
This longitudinal study investigated the impact of different Frequency Patterns (FP) on the syntactic production of a six-year-old EFL learner in a home context. Target syntactic constructions were presented using games and plays and were traced for their occurrence patterns in input and output. Following each instruction period, the constructions were measured through immediate and delayed ora...
متن کاملThe Impact of Interactive Output Tasks on Developing Vocabulary Knowledge of Iranian EFL Learners
This study investigated the role of interactive output tasks in developing EFL learners’ vocabulary knowledge. The participants were 103 elementary female Iranian EFL learners who were randomly divided into three groups: input-only, input-output-no-interaction, and input-output-interaction. After all participants took a placement test and a vocabulary pretest, the input-only group was exposed t...
متن کاملModular cell biology: retroactivity and insulation
Modularity plays a fundamental role in the prediction of the behavior of a system from the behavior of its components, guaranteeing that the properties of individual components do not change upon interconnection. Just as electrical, hydraulic, and other physical systems often do not display modularity, nor do many biochemical systems, and specifically, genetic networks. Here, we study the effec...
متن کامل